E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4 …

Specificity within the E2F family is achieved via multiple mechanisms, the first level of which comes from interactions with their negative regulators, the pocket proteins, pRB, p107 and p130.

In mammalian cells, the E2F family of transcription factors is an important downstream effector in a pathway activated by multiple signaling events, which controls the expression of genes …

May 3, 2019 · In this Review, we discuss the activities of E2F proteins with an emphasis on the newest atypical E2F family members, the specific and redundant functions of E2F proteins, …

Estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative cancer with a high E2F score achieved a significantly higher pathological complete response …

Jun 5, 2020 · The E2F family of transcriptional regulators sits at the center of cell cycle gene expression and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by …

Aug 1, 2004 · In this model, E2F target genes are actively repressed in G0/G1, whereas they are transactivated by E2F1–E2F3 in late G1 and S. Here, we summarize the efforts made to date …

Mar 15, 1999 · The E2F transcription factor plays a major role in cell cycle regulation, differentiation and apoptosis, but it is not clear how it is regulated by non‐mitogenic signaling …

Here we discuss the effects of E2F activity on signal transduction pathways and its potential biological consequences. The E2F family of transcription factors is most well known for its …

Jun 18, 2019 · Unbiased transcriptomic profiling of G 0, G 1 -S, and S-G 2 -M sorted cells from FUCCI mouse embryos suggested a central role for E2Fs in the control of cell-cycle …