Specifically, E2f indirectly affects the level and activity of p53 by upregulating the expression of many proteins that stabilize and activate p53. Examples include ARF, ataxia telangiectasia...

This review aims to introduce the expanding roles of the E2F-RB-p53 pathway in tumor suppression. Abstract. The transcription factor E2F links the RB pathway to the p53 pathway …

These findings suggest that p53 phosphorylation is a key step in E2F1-mediated apoptosis and that this modification can occur in the absence of p19ARF. The p53 tumor suppressor is an …

We show here that the cell cycle-dependent DNA-binding and transcriptional activity of p53 correlates with E2F expression in human primary fibroblasts. E2F1 binds and stimulates DNA …

We demonstrate that activation of E2F1 leads to phosphorylation of p53 on serine 46 and this modification is important for E2F1-p53 cooperation in apoptosis. Overall, these data provide …

This Review discusses the molecular mechanisms that underlie the intricate interactions between E2f and p53.

The results indicate that p53 differentially regulates the activities of two subclasses (E2F-1/-2/-3 vs. E2F-4/-5) of E2F transcription factors. Detailed analysis using a two-hybrid approach in …

Mar 17, 2005 · Four laboratories have now made significant in-roads into understanding E2F targets that play a role in p53-mediated apoptosis, and in so doing, have shed valuable new …

Jul 16, 2002 · The ability of deregulated E2F to induce ARF transcription provides one connection between the RB pathway and p53 (DeGregori et al., 1997; Bates et al., 1998) and may help to …

p53 and E2F-1 cooperate to mediate apoptosis. The tumor-suppressor protein p53 appears to function at the G1 phase of the cell cycle as a checkpoint in response to DNA damage. …