May 3, 2019 · Another molecule, the nucleoside analogue ly101-4B, has recently been identified as a potential E2F inhibitor 89. Ly101-4B was found to decrease E2F activity using a reporter …

E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators : E2F1, 2 and E2F3a. Six others act as repressors : E2F3b, E2F4-8.

May 9, 2018 · Here we confirmed that E2F1 is highly expressed in melanoma cells. Inhibition of E2F1 activity further increased melanoma cell death and senescence, both in vitro and in vivo. …

Our findings indicated that the E2F pathway score may be a potential predictive marker of response to NAC and a predictor of CDK inhibitor and immune checkpoint therapy in patients …

Previous work suggested that down regulation of total E2F activity within cancer cells would lead to either growth arrest or apoptosis, thus we predicted that a small molecule inhibitor of E2F …

Dec 7, 2023 · Histone deacetylase inhibitors (HDACis) have gradually become powerful anti-cancer agents targeting epigenetic modulation and have been widely used in the clinical …

A small-molecule pan-E2F inhibitor HLM006474 and the nucleotide analogue ly101-4B are reported to suppress E2F activity. Treatment of multiple cancer cell lines with HLM006474 …

Aug 1, 2008 · Treatment of multiple cell lines with HLM006474 resulted in the loss of intracellular E2F4 DNA-binding activity as measured by electrophoretic mobility shift assay within hours. …

The E2F Inhibitor, HLM006474, also referenced under CAS 353519-63-8, controls the biological activity of E2F. This small molecule/inhibitor is primarily used for Cancer applications.

Alterations in one or more key components of this axis (CDKs, cyclins, CDK inhibitors and the RB family of proteins) occur in virtually all cancers and result in heightened oncogenic E2F …