E2F - Wikipedia
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4 …
Two Distinct E2F Transcriptional Modules Drive Cell Cycles and ...
Using tagged-E2F knockin mice, imaging, and deep-learning tools, we mapped the spatial and temporal expression of E2F activators, canonical repressors, and atypical repressors during …
E2F2 - Wikipedia
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins …
Structural insights into the DNA-binding specificity of E2F family ...
Dec 3, 2015 · Our results define the binding specificity of the E2F family of transcription factors, and reveal the mechanism by which E2F8 is capable of regulating the cell cycle by directly …
Distinctions in the specificity of E2F function revealed by gene ...
The size and complexity of the E2F family of proteins reflect a complexity in function with individual E2Fs performing both distinct and overlapping roles in proliferation, apoptosis, and …
Overexpression of the E2F-1 Transcription Factor Gene Mediates …
The positions of molecular size markers and E2F-specific bands are as in (A). To determine whether E2F-1 could be overexpressed in cells other than Ψ-CRE, virus collected from the …
Transcription factor E2F binds DNA as a heterodimer. | PNAS
Apr 15, 1993 · E2F is a mammalian transcription factor that appears to play an important role in cell cycle control. DNA affinity column-purified E2F from HeLa cells reproducibly exhibits …
Atypical E2Fs: new players in the E2F transcription factor family
Feb 9, 2009 · Atypical E2F proteins represent an evolutionarily conserved branch of the E2F TFs family, in which the presence of a duplicated DBD provides these new E2F players with the …
E2F transcription factors and their complementary roles during …
In general, E2FA and E2FB are considered transcriptional activators, while E2FC is generally considered a repressor of cell proliferation (Sablowski and Gutierrez, 2022). In addition, it is …
E2F target genes: unraveling the biology - Cell Press
Aug 1, 2004 · The E2F transcription factors are crucial for regulating cell cycle progression and tumorigenesis. Therefore, to understand these biological processes, we need to unravel the …