Here we examined the capacity of EETs and DHETs to activate peroxisome proliferator-activated receptor-alpha (PPARalpha). We find that among the EET and DHET regioisomers, 14,15 …

Epoxyeicosatrienoic acids (EETs) are vasodilating lipid mediators metabolized into dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase. We aimed to develop a …

Oct 23, 2013 · EETs are hydrolyzed by soluble epoxide hydrolase (sEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs); thus, it is expected that the inhibition of this enzyme …

The CYP2C and CYP2J epoxygenases convert arachidonic acid into epoxyeicosatrienoic acid (EET) regioisomers (primarily 11,12- and 14,15-EET), which are converted into less-active …

Arachidonic acid is converted to epoxyeicosatrienoic acid (EET) by cytochrome P450 (CYP) epoxygenase. EETs primary metabolic fate is conversion to dihydroxyeicosatrienoic acids …

We constructed multivariable-adjusted linear regression models to compare 11,12-EET, 14,15-EET, 11,12-DHET, 14,15-DHET, total EET, total DHET, CYP epoxygenase function (EET+ …

Jan 1, 2006 · Here we examined the capacity of EETs and DHETs to activate peroxisome proliferator-activated receptor-α (PPARα). We find that among the EET and DHET …

Nov 19, 2020 · Both in vitro and in vivo research suggests that epoxyeicosatrienoic acid (EET) protects against NASH. Four biologically active EETs are generated from arachidonic acid by …

Epoxyeicosatrienoic acids (EETs) are metabolized by soluble epoxide hydrolase (sEH) to form dihydroxyeicosatrienoic acids (DHETs) and are putative endothelium-derived hyperpolarizing …

Jan 1, 2004 · Soluble epoxide hydrolase (sEH) converts EETs to dihydroxyeicosatrienoic acids (DHETs), and inhibition of sEH is a potential approach for enhancing the biological activity of …