Mar 30, 2025 · DDX21 (DExD-Box Helicase 21) is a Protein Coding gene. Diseases associated with DDX21 include Stomach Disease and Retinitis Pigmentosa 33 . Among its related pathways are rRNA processing in the nucleus and cytosol and RNA Polymerase I Promoter Opening .

Nov 24, 2014 · Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to control multiple steps of ribosome biogenesis in human cells.

Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene. [5][6] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.

Apr 4, 2024 · N6-methyladenosine (m 6 A) is a crucial RNA modification that regulates diverse biological processes in human cells, but its co-transcriptional deposition and functions remain poorly understood. Here, we identified the RNA helicase DDX21 with a previously unrecognized role in directing m …

DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal RNA (rRNA) processing, transcription, and translation. Its diverse functions in cancer progression and viral infections have attracted considerable attention.

RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood.

Apr 2, 2024 · DDX21, a member of the DEAD-box subfamily, is a multi-tasking RNA helicase that utilizes energy from ATP hydrolysis to the unwinding of structured RNA molecules, thereby enabling downstream RNA processing or remodeling of RNA–protein complexes. 22 DDX21 binds to various RNA substrates, such as rRNA, snoRNA, 7SK, and nucleic acid structures ...

Jan 5, 2023 · Glucose directly binds to the DDX21 ATP-binding domain and dissociates DDX21 dimers. Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during differentiation-associated intracellular glucose elevation.

Downregulation of DEAD-box helicase 21 (DDX21) inhibits proliferation, cell cycle, and tumor growth in colorectal cancer via targeting cell division cycle 5-like (CDC5L). DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication. The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.

Feb 12, 2015 · Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to control multiple steps of ribosome biogenesis in human cells.