Nov 24, 2015 · Here, we report an efficient Fmoc-deprotection solution containing piperazine and DBU which can cause complete removal of the Fmoc group in less than a minute. This …

Jul 8, 2000 · Catalytic DBU in the presence of an aliphatic or polymer-supported thiol rapidly removed the Fmoc group to provide the amine free base in excellent yields and purity on multi …

In this study, alternative Fmoc-removal solution 2% DBU (1,8-diazabicyclo[5.4.0]undec-7-ene)/5% piperazine/NMP (N-methyl-2-pyrrolidone) led to drastic DKP reduction relative to 20% …

May 1, 1991 · In this study, alternative Fmoc-removal solution 2% DBU (1,8-diazabicyclo[5.4.0]undec-7-ene)/5% piperazine/NMP (N-methyl-2-pyrrolidone) led to drastic …

Removal of Fmoc Protecting Group with DBU DBU-piperidine Deprotection Reagent. Dissolve 2.0 g of DBU and 2.0 mL of piperidine in DMF or NMP to make 100 mL. DBU Deprotection …

In summary, we have reported a strategy of Fmoc removal with 2% DBU, 5% piperazine/NMP that could evidently minimize both the “traceless” and ordinary DKP formation in SPPS. This …

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) removes the Fmoc protecting group much faster than piperidine. When Fmoc deprotection during a peptide synthesis is slow or incomplete, …

We found that the use of the stronger and more efficient base, DBU, at a concentration of 2% in DMF for Nalpha-Fmoc deprotection allowed substantially improved continuous flow solid …

The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step …

In the present study, we compare the kinetics of a few Fmoc-deprotection reagents and their combinations. Our results show that 5% piperazine + 2% DBU is faster than 20% piperidine …