The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the SLC6A3 gene (also known as DAT1), that pumps …

Mar 30, 2025 · Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of …

Human dopamine transporter gene. The DAT gene coding sequence is derived from 15 exons distributed across a >64 kb gene in humans. Whereas the human DAT coding region is of …

Mar 5, 2021 · In this review we summarize mechanisms governing DAT trafficking under normal physiological conditions and discuss how PD-linked mutations may disturb DAT homeostasis. …

The SLC6A3 gene provides instructions for making a protein called the dopamine transporter or DAT. This protein is embedded in the membrane of certain nerve cells (neurons) in the brain, …

SLC6A3 is the dopamine transporter (DAT) involved in the release and reuptake of dopamine from the synapse and extrasynaptic space into neurons and is integral to dopaminergic …

Epigenetic regulation of DAT gene promoter modulates the risk of externalizing and internalizing behaviors on a normative population: An explorative study. SLC6A3 as a potential circulating …

The dopamine transporter (DAT), which is encoded by the SLC6A3 gene, mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic …

Jun 1, 2005 · Of these, the dopamine transporter (DAT) is a principal target of the most widely used antihyperactivity medications (amphetamine and methylphenidate); the DAT gene is …

Feb 11, 2025 · DAT knockdown in the nucleus accumbens, but not in the caudate putamen, improve anxiety- and depression-like symptoms in adult mice and the data illustrate the …