Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene. [5][6] The expression of DUSP1 gene is induced in human skin fibroblasts by …

Mar 30, 2025 · DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Intellectual Developmental Disorder, X-Linked 108 and …

DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells. Extracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual …

Nov 7, 2023 · We found that Dusp1 expression was significantly upregulated in human transplant kidney tissue and mouse AKI tissue. Dusp1 gene deletion exacerbated acute ischemic injury, …

Here we report that DUSP1/MKP-1, the founding member of the DUSP family, plays a critical role in regulating autophagy. Specifically, we demonstrate that DUSP1 knockdown by shRNA in …

Dual-specificity phosphatases (DUSPs) are a subclass of protein tyrosine phosphatases (PTPs) that specifically interact with and regulate mitogen-activated protein kinases (MAPKs) by...

DUSP1 expression is induced after TLR triggering via MAPK activation and strongly enhanced by IL-10-STAT3 signaling. Preferential inhibition of p38 activity by DUSP1 down-regulates the …

As a protein phosphatase, DUSP1 also downregulates p38 MAPKs and JNKs signaling through directly dephosphorylating threonine and tyrosine. It has been detected that DUSP1 is …

Mar 3, 2025 · Finally, the use of HDAC1 inhibitors or adeno-associated virus-mediated DUSP1 overexpression in RTECs significantly ameliorated UUO-induced renal injury and fibrosis. …

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. Expressed at high levels in the lung, liver placenta and pancreas. Moderate …