007900 C57BL/6- Gt(ROSA)26Sor tm1(HBEGF)Awai /J The Cre-inducible expression of DTR in these iDTR knock-in mice render cells susceptible to ablation following Diphtheria toxin administration.

A new system for lineage ablation is based on transgenic expression of a diphtheria toxin receptor (DTR) in mouse cells and application of diphtheria toxin (DT). To streamline this approach, we generated Cre-inducible DTR transgenic mice (iDTR) in which Cre-mediated excision of a STOP cassette rende …

CD11c-DTR/GFP transgenic mice are useful in studies of mononuclear phagocyte origins and the specific role of dendritic cells in the immune response. In Goodwin et al. 2019 Genome Res. 29:494 , it was discovered that line 57 has more than 20 copies of the CD11c-DTR/GFP transgene inserted into the 1700016L21Rik locus on chromosome 1 (80448681 ...

May 20, 2005 · A new system for lineage ablation is based on transgenic expression of a diphtheria toxin receptor (DTR) in mouse cells and application of diphtheria toxin (DT).

016958 B6.129(Cg)- Foxp3 tm3(HBEGF/GFP)Ayr /J Foxp3 DTR knock-in mice express the human diphtheria toxin receptor (designated heparin-binding EGF-like growth factor [HBEGF]) and EGFP genes from the Foxp3 locus--without disrupting expression of the …

为助力免疫机制研究，上海南模生物自主研发一系列免疫研究相关的DTR小鼠，包含 B 细胞、T 细胞、NK 细胞、Treg 细胞等等特异性的 DTR 小鼠。 此外研发了条件性表达的 iDTR 小鼠 ，通过和特异性 Cre 小鼠以及 Dre 小鼠交配，能实现更多类型的细胞特异性剔除。

Jul 5, 2018 · Conversely, transgenic expression of a primate proHB-EGF/DTR renders resistant mouse cells DTx sensitive 9, providing a system for a versatile toxin-induced cell ablation in vivo.

Aug 1, 2001 · We have developed a simple and sensitive method for conditional cell ablation in transgenic mice, called “toxin receptor–mediated cell knockout.” We expressed the diphtheria toxin (DT) receptor in...

Feb 26, 2012 · Transgenic mice expressing the diphtheria toxin receptor (DTR) in specific cell types are key tools for functional studies in several biological systems. B6.FVB-Tg (Itgax-DTR/EGFP)57Lan/J...

By mating this mouse, nicknamed the Terminator mouse (Rosa-DTR flox), to an appropriate Cre strain, DTR expression is permanently removed from cells that express Cre at any time prior to diphtheria toxin selection.