Dec 25, 2017 · Adding DNMT1 inhibitor (5-Aza-2dc) or HDAC1 inhibitor (LBH589) depressed the up-regulation of DNMT1 or HDAC1 expression, the decreases of GSH levels and increases of …

Our results indicate that DNMT1 forms a stable complex with Rb, E2F1 and HDAC1, and that this association is capable of repressing transcription from promoters containing E2F1-binding sites.

Here we show that the predominant mammalian DNA methyltransferase, DNMT1, co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1 and that DNMT1 …

Sep 12, 2024 · Epigenetic therapies have emerged as a key paradigm for treating malignancies. In this study, a series of DNMT1/HDAC dual inhibitors were obtained by fusing the key …

The non-catalytic amino terminus of DNMT1 binds to HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression.

Nov 2, 2010 · Our model suggests that DNMT1, HAUSP, Tip60, UHRF1, HDAC1, and PCNA form a macromolecular protein complex that binds at the DNA replication fork to coordinately …

Mar 15, 2024 · DNMT1 and HDAC1 are overexpressed and inhibitors of these enzymes exert synergistic effects in human breast cancer

Jan 27, 2014 · We identify two important epigenetic regulators, HDAC1 and DNMT1, which are highly associated with the RGS10 promoter in chemoresistant ovarian cancer cells. HDAC1 …

Sep 8, 2006 · While HDAC1 revealed an additional signal in the nuclei of somatic Sertoli cells, DNMT1 gene expression was restricted to germ cells exhibiting positive signals for DNMT1 …

Dec 25, 2017 · DNMT1 and HDAC1 were significantly activated at mRNA and protein levels. The significant increasing of expression of DNMT1 and HDAC1 was observed in PK15 cells …

The non-catalytic amino terminus of DNMT1 binds to HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression. DMAP1 has intrinsic …

Jun 1, 2024 · In this study, we showed that the simultaneous knockdown of HDAC1 and DNMT1 limited tumour proliferation. J208, a bifunctional HDAC and DNMT inhibitor, had strong …

May 11, 2017 · Here we show that knockdown of HDAC3, but not HDAC1 or HDAC2, as well as BG45, downregulate expression of DNA methyltransferase 1 (DNMT1) mediating MM cell …

Here we show that knockdown of HDAC3, but not HDAC1 or HDAC2, as well as BG45, downregulate expression of DNA methyltransferase 1 (DNMT1) mediating MM cell …

Jan 27, 2014 · We identify two important epigenetic regulators, HDAC1 and DNMT1, which are highly associated with the RGS10 promoter in chemoresistant ovarian cancer cells. HDAC1 …

Consistent with this association, we find that one of the known histone deacetylases, HDAC1, has the ability to bind Dnmt1 and can purify methyltransferase activity from nuclear extracts.

Aug 1, 2024 · Moreover, silencing of HDAC1 downregulated the DNMT1 expression by inhibiting c-MYC [38], [39], we found that knocking down HDAC1 could suppress the DNMT1 …

DNA methylation catalyzed by DNA methyltransferases (DNMTs) and histone deacetylation catalyzed by histone deacetylases (HDACs) play an important role for the regulation of gene …

Sep 14, 2017 · Western blot analysis revealed significant decreases in DNMT1, HDAC1, and HDAC2 protein levels 1 and 30days after irradiation with 10Gy. Furthermore, protein levels of …