Aug 11, 2011 · We identified two genes encoding transcription factors, sp6-9 and dlx, that were expressed in the eye specifically in the optic cup and not the photoreceptor neurons. RNAi of these genes prevented formation of visible optic cups during regeneration.

Mar 3, 2007 · Sp9 encodes a buttonhead-like C 2 H 2 zinc-finger transcription factor highly related to Sp8. Expression of Sp9 in the subpallium and OB is very similar to Dlx1 and GAD67 (Fig. 3 A–F,G–L).

We propose that DLX1/2 promote OB interneuron development mainly through activating the expression of Sp8/9, which further promote Tshz1 and Prokr2 expression. Based on this study, in combination with earlier ones, we propose a transcriptional network for the process of OB interneuron development.

Aug 1, 2017 · Sp8/Sp9-DCKO mice developed weakness from birth and died between P5 and P12. Compared with Dlx5/6-CIE control OBs, Sp8/Sp9-DCKO OBs were severely reduced in size at P4 and P11 (Fig. 2A–B′).

Jul 23, 2018 · SP8 and SP9 together drive expression of the transcription factor Six3 in a spatially restricted domain of the LGE subventricular zone. Conditional deletion of Six3 also prevents the formation of most D2 MSNs, phenocopying the Sp8/9 mutants.

Sep 1, 2018 · Here we show that Sp8 and Sp9 coordinately regulate OB interneuron development: although Sp9 null mutants show no major OB interneuron defect, conditional deletion of both Sp8 and Sp9 resulted in a much more severe reduction of OB interneuron number than that observed in the Sp8 conditional mutant mice, due to defects in neuronal ...

We identified two genes encoding transcription factors, sp6-9 and dlx, that were expressed in the eye specifically in the optic cup and not the photoreceptor neurons. RNAi of these genes prevented formation of visible optic cups during regeneration.

Jul 23, 2018 · Sp8/9-DCKO mice, compared with Sp8-CKO and Sp9-KO, have a more severe reduction of D2 MSNs. This is mainly due to severely reduced LGE neurogenesis. Crucially, Sp8 and Sp9 are required for expression of the TF Six3 in the SVZ of pLGE3.

Aug 11, 2011 · We identified two genes encoding transcription factors, sp6-9 and dlx, that were expressed in the eye specifically in the optic cup and not the photoreceptor neurons. RNAi of these genes prevented formation of visible optic cups during regeneration.

It is proposed that DLX1/2 promote OB interneuron development mainly through activating the expression of Sp8/9, which further promote Tshz1 and Prokr2 expression. It is demonstrated that PROK2/PROKR2 signaling is crucial for the tangential and radial migration of OB interneurons in the SVZ‐RMS‐OB.