DDX5 is involved in the selective splicing of H-Ras proto-oncogenes. H-Ras can be selectively spliced into two proteins, p21 H-Ras and p19 H-Ras. DDX5 produces the oncogene p21 H-Ras by inhibiting the recognition and splicing of the intron D exon (IDX), which can contribute to the development of cancer (33).

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the treatment of various cancer types.

Jan 23, 2012 · In this work, we report that ddx5 and ddx17 have a dual role in the control of the pro-migratory NFAT5 transcription factor. First, ddx5 and ddx17 act as transcriptional coactivators of NFAT5 and...

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene. [5] DEAD box proteins, characterized by the conserved motif Asp - Glu - Ala -Asp (DEAD), are putative RNA helicases.

Jan 1, 2019 · DDX5 is implicated in tumorigenesis, proliferation, metastasis and differentiation in human malignancies. Cancer-related pathways modulated by DDX5 are potential targets in cancer diagnosis, prognosis and therapy. Pre-clinical studies of drugs targeting DDX5 have shown great promise.

P68 RNA helicase regulates the alternative splicing of the important proto-oncogene H-Ras, and numerous studies have shown that p68 RNA helicase is probably involved in miRNA biogenesis, mainly through Drosha and RISC/DICER complexes.

he literature, we found that the multiple functions of DDX5 make it both a superior independent oncogenic biomarker and target for targeted cancer therapy. In this article, we will summarize the relevant studies on DDX5 in literature with a careful analysis

Here, we show that the DEAD box RNA helicase 5 (DDX5) is overexpressed in alveolar RMS cells and that its depletion and pharmacological inhibition decrease FP-RMS viability and slow tumor growth in xenograft models.

Aug 13, 2008 · Here we show that p68 unwinds the stem-loop IDX-rasISS1 structure and prevents binding of hnRNP H to IDX-rasISS1. We also found that p68 alters the dynamic localization of SC35, a splicing factor that promotes IDX inclusion.

An additional role of DDX5 in splicing has been demonstrated by studies that show a role in the alternative splicing of the proto-oncogene c- H-ras [48]. In addition to its role in RNA processing, DDX5 might also contribute to the regulation of transcription.