Sep 17, 2012 · The RNA helicase p68 (DDX5) is an established co-activator of the p53 tumour suppressor that itself has a pivotal role in orchestrating the cellular response to DNA damage.

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a …

Aug 19, 2023 · In this review, we discuss the multifaceted functions of DDX5 in DNA repair in cancer, immune suppression, oncogenic metabolic rewiring, virus infection promotion, and …

May 23, 2019 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in …

Nov 1, 2011 · Taken together, our findings indicate that DDX5 is a key p53-independent target of the ARF tumor suppressor and is a novel non-oncogene participant in ribosome biogenesis.

Jul 18, 2013 · In the present study, we show that, while p68 is critical for p53-mediated transactivation of the cell-cycle arrest gene p21 (WAF1/CIP1), it is dispensable for induction of …

The tumor suppressor p53 facilitates the repair of DNA damage, thereby preventing malignant transformation or inducing resistance to chemotherapy in cancer. This study reveals that p53 …

In this study, we examined whether DDX5 contributes to the activation of tumor suppressor genes and induction of cell death by deregulated E2F1. We also examined whether the effect of …

Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves …

Dec 10, 2024 · Over-expression of DDX5 enhanced E2F1 induction of tumor suppressor gene expression and cell death. Conversely, shRNA-mediated knockdown of DDX5 compromised …