In both cases, Ddx5 is recruited to Myod and Runx2 responsive promoters, and it enhances their transcriptional activity. During myogenesis, one consequence is the induced expression of myogenic microRNAs, myogenic transcription factors …

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the treatment of various cancer types.

Using an inducible knockout mouse model, we characterise an essential role for DDX5 in spermatogonial maintenance and show that Ddx5 is indispensable for male fertility. We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis.

Jun 26, 2014 · DDX5 and DDX17 cooperate with heterogeneous nuclear ribonucleoprotein (hnRNP) H/F to control splicing subprograms in epithelial cells and myoblasts. They help to initiate differentiation-specific transcription programs as transcriptional coregulators.

Aug 1, 2013 · As for MyoD, p68 is recruited to the Runx2-responsive osteocalcin promoter and simultaneous p68/p72 siRNA knockdown inhibited Runx2 transcriptional activity. However, p68/p72 depletion in C2C12 osteoblast progenitor cells accelerated their differentiation, suggesting that the role of p68/p72 in this process is complex [41] .

Aug 30, 2022 · Here, we show that the DEAD box RNA helicase 5 (DDX5) is overexpressed in alveolar RMS cells and that its depletion and pharmacological inhibition decrease FP-RMS viability and slow tumor growth in xenograft models.

Aug 19, 2016 · By immunoprecipitation analysis, Caretti et al. (2006) found that p68, p72 (DDX17; 608469), and the noncoding RNA SRA (SRA1; 603819) associated with MYOD (MYOD1; 159970) in MYOD-transfected HeLa cells.

the multiple functions of DDX5 make it both a superior independent oncogenic biomarker and target for targeted cancer therapy. In this article, we will summarize the relevant studies on DDX5 in literature with a careful analysis

DDX5/DDX17 are coreguulators of p53, and DDX5 selectively regulates p53 mediation of growth arrest or apoptosis; DDX5 positively regulates the expression of p53 by inhibiting Δ133p53. In contrast, DDX17 negatively regulates p53 expression by inducing Mdm2 expression.

Apr 23, 2019 · We provide evidence that DDX5 expression enhances Fra-1 transcriptional activity and potentiates Fra-1-driven cell proliferation. Furthermore, we show that the DDX5 target gene signature...