000671 DBA/2J DBA/2J is a widely used inbred strain. The strain characteristics include: susceptibility to audiogenic seizures; high-frequency hearing loss; comparative resistance to diet-induced atherosclerosis; development of progressive eye abnormalities that closely mimic human hereditary glaucoma; affinity for methamphetamine; and extreme ...

DBA/1J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions on an atherogenic diet. In response to challenge, DBA/1J mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease.

DBA/1 mice are known for their susceptibility to autoimmune diseases, whereas DBA/2 mice are characterized by their tendency to develop ocular defects. Moreover, DBA/2 mice show greater genetic variability than DBA/1 mice and are considered more suitable for …

DBA/1和DBA/2虽然是从DBA中筛选出的两个亚系，但是他们之间的基因位点差别比较大，甚至包括 MHC H2 不同。 可能是由于但是建立的DBA品系中杂合性较高。 用 II型胶原 进行免疫可引发严重的由自身免疫应答介导的多发性关节炎，因此DBA/1J小鼠就被作为研究类风湿性关节炎的模型广泛使用。 根据实验记录可知胶原诱导的关节炎发病率高低不一，但都不超过100%。 与人类的 …

DBA/2 mice failed to react to a spatial change of objects in an open field, and therefore resemble rats with dorsal lesions of the hippocampus. They may represent a model of hippocampal dysfunction (Ammassari_Teule et al, 1995).

Nov 5, 2003 · DBA/2 mice are homozygous for a mutation for aging-related hearing loss (ah1), resulting in detectable high-frequency impairment (and progressive cochlear pathology) by the time of weaning and severe impairment by 2 to 3 months of age. Young individuals are prone to audiogenic seizures.

Strain DBA/2 (formerly dba, then DBA) is the most ancient of all inbred strains since it was established by C. C. Little in 1909 [47], by intercrossing mice homozygous for the coat colour markers non-agouti (a), brown (formerly b, now Tyrp1) and dilute (formerly d, now Myo5a).

Dec 4, 2018 · DBA/2J mice show moderate to high placidity. The most notable feature of this strain is high resistance to atherosclerosis and vascular lesions.

DBA/2J strain is distinct from the C57BL/6J strain and exhibits unique characteristics. DBA/2J mice show a low susceptibility to developing atherosclerotic aortic lesions following 14 weeks on an atherogenic diet.

DBA/2 mice have significantly higher basal levels of kappa opioid receptor mRNA in the hypothalamus than C57BL/6 mice (Winkler and Spanagel 1998) and significantly higher kappa-opioid binding sites, prodynorphin mRNA, dynorphin A 1-13 and dynorphin A 1-8 peptides in the nucleus accumbens than C57 mice (Jamensky and Gianoulakis 1997).