The role of cyclophilin A (CypA) and nuclear factor of activated T cells (NFAT) in CsA-imposed suppression of BKV replication was determined in this study. Results demonstrated that knockdown of CypA but not CypB significantly reduced …

This research proved that MgPa could interact with host cell Cyclophilin A (CypA) and prevent T cell activation by inhibiting Calcineurin (CaN) phosphorylation and NFAT nuclear translocation, which clarified the immunosuppression mechanism of M. genitalium to host T cells.

CsA inhibits BKV replication through CypA and NFAT, which may be po-tential targets of anti-BKV treatment.

Our findings revealed important mechanisms that regulate NF-κB activation, and offer new insights into the role of CypA in aberrant activation of NF-κB-mediated signaling for altered expression of its target genes, resulting in pathological effects in various diseases.

CypA-NS5A interactions control the formation of DMVs that protect the newly synthesized viral genome from recognition by immune host sensors. (Mamatis et al., 2022). Furthermore, CypA is a master regulator of the innate antiviral immune response through multiple avenues.

May 25, 2011 · The role of cyclophilin A (CypA) and nuclear factor of activated T cells (NFAT) in CsA-imposed suppression of BKV replication was determined in this study. Results demonstrated that knockdown of CypA but not CypB significantly reduced BKV large T …

Jan 21, 2004 · Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin.

Dec 10, 2022 · Here, we demonstrate that ZAP70 in TCR/CD3-activated mouse spleen and thymus cells, as well as human Jurkat T cells, is regulated by the peptidyl-prolyl cis–trans isomerase (PPIase), cyclophilin A (CypA) and that this regulation is abrogated by cyclosporin A (CsA), a CypA inhibitor.

Jun 15, 2023 · This research proved that MgPa could interact with host cell Cyclophilin A (CypA) and prevent T cell activation by inhibiting Calcineurin (CaN) phosphorylation and NFAT nuclear translocation, which clarified the immunosuppression mechanism of M. genitalium to host T cells.

factor of the activated T-cells (NFAT) pathway [5-7]. CyPA can be intracellularly and extracellularly expressed in many cell types, e.g., vascular smooth muscle cells (VSMCs), endothelial cells, macrophages, and kidney cells [8, 9]. As a result, CyPA serves as a multifunctional protein [8, 9]. Although the roles for