Cyclin-H is a protein that in humans is encoded by the CCNH gene. [5][6] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by …

All cyclins have one or two cyclin boxes, but the domain is found in other proteins as well, such as pRb and TFIIB. The cyclin box is key to the two most important features of the cyclins with …

Mar 30, 2025 · CCNH (Cyclin H) is a Protein Coding gene. Diseases associated with CCNH include Capillary Malformation-Arteriovenous Malformation 1 and Basal Cell Carcinoma 1. …

Jul 10, 2021 · This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK …

The specificity of the cyclin H molecule is provided mainly by two long helices which extend the cyclin fold at its N- and C-termini and pack together against the first repeat on the side …

Feb 9, 2025 · The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the …

Nov 23, 2023 · Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each …

Cyclin H/Cdk7, components of Cdk-activating kinase (CAK), enhances the activity of SR and, in some cases, directly phosphorylates the SR. Overexpression of CAK stimulates the …

Aug 8, 1996 · We have determined the X-ray crystal structure of the regulatory subunit of CAK, cyclin H, at 2.6 A resolution. Cyclin H contains two alpha-helical core domains with a fold …

Cyclin H is a member of the cyclin family that regulates multiple cell cycle transitions and is expressed in normal post-mitotic neurons. It is involved in DNA repair in neurons as well as …