Unlock the power of the Cre/lox system for tissue-specific, inducible knockouts and advanced gene tracking in mouse models. Learn practical breeding schemes to simplify complexity, …

May 19, 2006 · To use Cre-lox technology, an investigator has to produce a Cre-lox mouse, typically by breeding a Cre mouse to a loxP mouse. A Cre mouse contains a Cre recombinase …

Jan 21, 2025 · Cre-lox technology initially represented the pinnacle of sophistication; but as it drove scientific breakthroughs and advanced understanding, more refined questions arose, …

In a previous post I discussed breeding Cre/lox mice to generate tissue-specific and inducible conditional knockout mouse strains. I would now like to continue the discussion of breeding …

Research Tools: Cre-Lox and More FAQ. Find answers to questions like: How do Cre-Lox and Tet-on / Tet-off systems work? Does my mouse need to be homozygous for cre? What is the …

The Cre-lox system is one of the most revolutionary tools in the geneticist's toolbox. You don't have to be a user or developer of cre or floxed mice to appreciate the impact that cre-lox …

Conditional mutagenesis using the Cre-lox system is not the only strategy available to spatiotemporally regulate gene expression in mouse models of human diseases.

In a recently published paper (Heffner, et al. 2013) researchers at The Jackson Laboratory have found that many strains expressing Cre have phenotypes that were not obvious when these …

The Cre/lox system has become the cornerstone of modern mouse genetics because it enables sophisticated control over the timing and location of gene expression. This is the first in a …

With tissue-specific Cre-lox KO models, the genotype of the mice that you generally want to evaluate is homozygous for your floxed allele (fl/fl) and positive for Cre (cre+). (Typically, only …