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A novel cereblon modulator recruits GSPT1 to the CRL4 CRBN
Jun 22, 2016 · Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4 CRBN E3 ubiquitin ligase. Here we report the identification …
- Author: Mary E. Matyskiela, Gang Lu, Takumi Ito, Barbra Pagarigan, Chin-Chun Lu, Karen Miller, Wei Fang, Nai...
- Publish Year: 2016
Discovery of First-in-Class PROTAC Degraders of SARS …
Apr 12, 2024 · MPD2 effectively reduced M Pro protein levels in 293T cells, relying on a time-dependent, CRBN-mediated, and proteasome-driven mechanism. Furthermore, MPD2 exhibited remarkable efficacy in diminishing …
Lenalidomide Causes Selective Degradation of IKZF1 …
Nov 28, 2013 · Western blots of 293T cells lysates 48 hours after cotransfection of FLAG-tagged IKZF3 or IKZF4 with HA-tagged CRBN and 24 hours of drug …
- Author: Jan Krönke, Namrata D. Udeshi, Anupama Narla, Peter Grauman, Slater N. Hurst, Marie McConkey, Tanya ...
- Publish Year: 2014
Discovery of novel potential CRBN modulators through structure …
Dec 1, 2022 · CRBN protein is an E3 ubiquitin ligase which plays an important role in the ubiquitin-proteasome system of eukaryotic cells. Small molecules can modulate CRBN and …
Cereblon attenuates DNA damage-induced apoptosis by …
Jan 25, 2019 · Human embryonic kidney (HEK) 293T cells were first transfected with siNC or siCRBN for 24 h and then co-transfected again with GFP or GFP-p53 and Flag-Bcl-2 (c) or …
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CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and …
Jan 25, 2018 · CRBN is a substrate receptor for the Cul4A/B-DDB1 ubiquitin ligase (CRL4) and can target voltage- and calcium-activated BK channel for ER retention. Here we report that ID …
CRBN Knockout cell line(293T) - Ubigene
The CRBN Knockout cell line(293T) is constructed based on (1) the optimal design of the Red Cotton System, (2) CRISPR-U™ technology with efficiency 10-20 times higher than traditional …
CRBN Knockout Cell Line-HEK293T - creative-biogene.com
Host Cell: HEK293T Target Gene: CRBN. Size: >1x10^6 cells/vial Validation: Sequencing. This cell line is a stable cell line with a homozygous knockout of human CRBN using …
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Glutamine Triggers Acetylation-Dependent …
Mar 17, 2016 · Cereblon (CRBN), a substrate receptor for the cullin-RING ubiquitin ligase 4 (CRL4) complex, is a direct protein target for thalidomide teratogenicity and antitumor activity of immunomodulatory drugs (IMiDs). Here …
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