Cellular retinoic acid-binding protein 1 is a protein that in humans is encoded by the CRABP1 gene. [5] [6] CRABP1 is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid.

Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains largely unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of …

Cellular binding-proteins (BP), including CRBP1, CRBP2, CRABP1, CRABP2, and FABP5, shepherd the poorly aqueous soluble retinoids during uptake, metabolism and function.

Mar 30, 2025 · CRABP1 (Cellular Retinoic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with CRABP1 include Teratocarcinoma and Embryonal Carcinoma . Among its related pathways are Signaling by Retinoic Acid and ESR-mediated signaling .

Four cellular retinol BP (CRBP) have been identified that bind retinol and retinal specifically, along with two cellular BP (CRABP) that bind all- trans -retinoic acid (atRA) with high affinity.

May 1, 2019 · Cellular retinoic acid binding protein 2 (CRABP2) binds to and transports RA from the cytoplasm to the nucleus. Because of its direct interaction with RARs bound to retinoic acid responsive elements (RARE) in the promoters of RA target genes, CRABP2 specifically channels RA to chromatin-bound nuclear receptors, which then mediate ...

The two cellular retinoic acid binding proteins, CRABP I and CRABP II, belong to a family of small cytosolic lipid binding proteins and are highly conserved during evolution. Both proteins are expressed during embryogenesis, particularly in the developing nervous system, craniofacial region and limb …

Loss of cellular retinoic acid binding protein 1 function due to hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma; CRABP I plays an important role not only in mediating the retinoid effects, but also in modulating the radiation sensitivity of tumour cells after combined retinoic acid radiation treatment.

Crbp2 in the small intestine enterocyte prevents massive ATRA biosynthesis from retinal generated by dietary β-carotene cleavage. Outside the intestine, Crbp1 chaperones retinol and retinal for ATRA biosynthesis.

Mar 8, 2022 · We hereby have identified CRABP-II as a novel player in pancreatic cancer lipid metabolism, and our observation that CRABP-II is overexpressed in PDAC but not detectable in normal pancreas and chronic pancreatitis justifies CRABP-II as …