Rab7: A Key to Lysosome Biogenesis - PMC - PubMed Central …
In this study, we have expressed Enhanced Green Fluorescent Protein (EGFP)–tagged Rab7 wt as well as active and dominant-negative mutant proteins and analyzed their effect on the …
Rab7: A Key to Lysosome Biogenesis - Molecular Biology of the Cell
Oct 13, 2017 · In this study, we have expressed Enhanced Green Fluorescent Protein (EGFP)–tagged Rab7 wt as well as active and dominant-negative mutant proteins and …
A trimeric Rab7 GEF controls NPC1-dependent lysosomal ... - Nature
Nov 3, 2020 · Loss of the Rab7-NPC1 interaction in MCC-deficient cells correlates with lysosomal cholesterol accumulation, suggesting Rab7 activation is essential for NPC1-dependent …
Endo-Lysosomal Vesicles Positive for Rab7 and LAMP1 Are …
Lacking from previous work is an examination of Rab7 and LAMP1 simultaneously. Using confocal fluorescence microscopy to image Rab7 and LAMP1, we find that the majority (70%) …
RAB7 Controls Melanoma Progression by Exploiting a Lineage …
Jul 14, 2014 · Alonso-Curbelo et al. identify a unique dependency in melanoma on the small GTPase RAB7 due to regulation by both oncogenic and lineage-specific factors. RAB7 …
Salmonella Impairs RILP Recruitment to Rab7 during Maturation …
Acquisition of Rab7 and its effector protein RILP to the SCV were studied using confocal fluorescence microscopy. Because available antibodies are inadequate to detect the …
Mon1–Ccz1 activates Rab7 only on late endosomes and dissociates from ...
Jan 15, 2016 · A combination of a Rab7 sensor and confocal FRET imaging techniques revealed that the activation of Rab7 on late endosomes depends on Mon1–Ccz1 and is implicated in …
The Rab7 effector protein RILP controls lysosomal transport by …
Oct 30, 2001 · We and others have identified a protein, called RILP (for Rab7-interacting lysosomal protein), that interacts with active Rab7 on late endosomes and lysosomes. Here …
B cell endosomal RAB7 promotes TRAF6 K63 polyubiquitination …
RAB7 overexpression in Cd19+/creRosa26fl-STOP-fl-Rab7 mouse B cells upregulates K63 polyubiquitination activity of TRAF6, enhances NF-κB activation and AID induction, and boosts …
Control of RAB7 activity and localization through the …
Nov 20, 2017 · Confocal analysis of endogenous RAB7 and LAMP2 revealed a pronounced increase in co‐localization in VPS29 CRISPR‐transfected cells which were used as positive …