Oct 27, 2023 · Cardiac fibroblast–specific Vcan deletion was achieved using the mouse strains Col1a2-2A-CreER and Vcan fl/fl. Molecular signaling pathways related to the effects of …

Aug 26, 2020 · The tamoxifen-inducible, fibroblast-specific conditional knockout mouse line (Col1a2-Cre/ERT2*Txndc5 fl/fl) used in the present study allows efficient deletion of Txndc5 in...

Jul 12, 2020 · In CKO mice, Il11ra1 is deleted in Col1a2 +ve cells only after tamoxifen treatment. To induce conditional knockdown of Il11ra1 in fibroblasts, we injected 8-week old CKO mice …

Dec 1, 2023 · Next, we generated tamoxifen-induced Col1a2-Cre-ERT2::Mmp14 KO mice (Mmp14 conditional knockout (CKO)). The CKO mice developed hind limb dorsiflexion and …

Collagen alpha-2(I) chain is a protein that in humans is encoded by the COL1A2 gene. [5] [6] This gene encodes one of the chains for type I collagen, the fibrillar collagen found in most …

Importantly, similar results were observed using a different Cre driver (Col1a2-CreERT) to induce deletion of both Yap and Taz in cardiac fibroblasts prior to MI 25. Targeted inhibition of both …

To test the role of mesenchymal RelA in AAA formation, we generated RelA conditional knockout (RelA-CKO) mice by administering tamoxifen to double transgenic mice harboring RelA-flox …

Type I collagen (COL), which harbors two CYP1 chains (COL1A1) and a single CYP2 chain (COL1A2) (6, 7), has unique biochemical and biomechanical properties. Some study has …

Mar 30, 2025 · COL1A2 (Collagen Type I Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL1A2 include Osteogenesis Imperfecta, Type Iv and Osteogenesis …

Survival analysis showed that COL1A2 was a reliable predictor for distinguishing the status of disease-specific survival (DSS), overall survival (OS), and progression-free survival (PFS), …