Minimizing DNA trapping while maintaining activity inhibition via ...
Dec 18, 2024 · Poly ADP-ribose polymerase 1 (PARP1) plays a pivotal role in DNA repair [1, 2, 3]. Upon detection of DNA damage, PARP1 binds to the site of DNA breakage and catalyzes …
Uncoupling of PARP1 trapping and inhibition using selective PARP1 ...
Oct 28, 2019 · PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). The relative contribution of these two …
Identification of Poly (ADP-ribose) Polymerase-1 (PARP-1) as a …
Jun 6, 2011 · Using co-immunoprecipitation (co-IP), mass spectrometry, and GST pulldown assays, we identified poly (ADP-ribose) polymerase-1 (PARP-1) as a novel KLF8-interacting …
Cycloheximide-induced T-cell Death Is Mediated by a Fas …
In this study, the molecular mechanisms of CHX-induced cell death were examined in two different human T-cell lines. In T-cells undergoing CHX-induced apoptosis (Jurkat), but not in …
Transcriptional regulation mechanism of PARP1 and its …
Aug 8, 2024 · Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic …
TNF-induced necroptosis and PARP-1-mediated necrosis …
First, DNA-alkylating agents such as 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) or methyl methanesulfonate rapidly activate the PARP pathway, whereas this is a late and secondary …
PARP1 promotes gene expression at the post-transcriptional level …
Mar 8, 2017 · Here we show that, in response to LPS exposure, PARP1 interacts with the adenylateuridylate-rich element-binding protein embryonic lethal abnormal vision-like 1 …
PARP1: Structural Insights and Pharmacological Targets for …
In this review, we provide a general overview of PARP1 and emphasize novel potential approaches for pharmacological inhibition. Clinical PARP1 inhibitors bind the catalytic pocket, …
PARP1 - Wikipedia
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly [ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] It is …
A unified mechanism for PARP inhibitor-induced PARP1 …
May 28, 2024 · Employing newly introduced measures of PARP1 dynamics and activity in vivo, Kanev et al. reveal that both catalytic inhibition and allosteric trapping by PARP inhibitors …
- Some results have been removed