Congenital hypertrophy of the retinal pigment epithelium is a typically benign, asymptomatic, pigmented fundus lesion. A congenital hamartoma of the retinal pigment epithelium (RPE), CHRPE occurs in 3 variant forms: solitary (unifocal), grouped (multifocal), and atypical.

Optical coherence tomography (OCT) through CHRPE lesions demonstrate thickened hyperreflective RPE with overlying absent or thinning of outer retinal layers and photoreceptor loss [10].

study CHRPE in 18 patients with imaging modalities including camera-based fundus autofluorescence imaging, infrared reflectance (IR) imaging, and spectral domain (SD) enhanced depth imaging OCT (EDI-OCT). The use of SD-OCT and EDI-OCT allows for greater resolution of retinal structures and improved visualization of the choroid.4 Methods

The CHRPE is a benign uncommon finding that occurs due to a proliferation of the cells of the pigmented epithelium. It is frequently a flat or minimally elevated pigmented, round, oval lesion, with well-delimited margins that emerge from the periphery of the ocular fundus.

OCT is a valuable diagnostic tool for evaluation of tissue architecture of the postequatorial fundus (inner retina, outer retina, retinal pigment epithelium (RPE), and choroid). In ocular oncology, OCT allows for diagnosis, treatment planning, and monitoring response.

Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is characterized by darkly pigmented, benign lesions in the retina, often detected during routine eye examinations. It is typically asymptomatic and does not require treatment.

On EDI-OCT, CHRPE seems flat with thickened, irregular RPE and absent RPE within lacunae. A prominent feature is outer retinal loss, generally involving the outer nuclear layer to photoreceptors, occasionally with a characteristic subretinal cleft.

Mar 28, 2022 · CHRPE Photographer Meghan Menzel, University of Iowa Imaging device Optical coherence tomography system Description Optical coherence tomography image over a CHRPE lesion. Related files

May 15, 2024 · Congenital hypertrophy of the retinal pigmented epithelium (CHRPE) is a benign ocular condition characterized by well-defined, flat, pigmented lesions primarily located in the fundus of the eye.

We describe the clinical and OCT features of CHRPE using the 5 radial lines acquisition OCT protocol over the CHRPE and the retina next to the tumor. Results: The mean patient age was 54 years (median 57 years; range 8-76 years).