Congenital hypertrophy of the retinal pigment epithelium is a typically benign, asymptomatic, pigmented fundus lesion. A congenital hamartoma of the retinal pigment epithelium (RPE), CHRPE occurs in 3 variant forms: solitary (unifocal), grouped (multifocal), and atypical.

Optical coherence tomography (OCT) of RPE hypertrophy will demonstrate both thickening and thinning. The overlying retina is thinned, the retinal pigment epithelium is both thickened or can be thinned. The underlying choroid is typically thinned.

Congenital hypertrophy of the retinal pigment epithelium is a rare benign tumor of the ocular fundus that may vary according to three types. It is frequently asymptomatic and diagnosed during routine ophthalmology exam.

On EDI-OCT, CHRPE seems flat with thickened, irregular RPE and absent RPE within lacunae. A prominent feature is outer retinal loss, generally involving the outer nuclear layer to photoreceptors,

Optical coherence tomography (OCT) through CHRPE lesions demonstrate thickened hyperreflective RPE with overlying absent or thinning of outer retinal layers and photoreceptor loss [10].

The information contained here should be used as general guidance when viewing opto map and OCT images from Optos devices. The differential diagnosis should be made under the direction of the responsible physician. These images were taken on …

Objective: To describe the cross-sectional retinal anatomy overlying congenital hypertrophy of the retinal pigment epithelium (CHRPE) using optical coherence tomography (OCT). Design: Retrospective, observational, noncomparative case series. …

On EDI-OCT, CHRPE seems flat with thickened, irregular RPE and absent RPE within lacunae. A prominent feature is outer retinal loss, generally involving the outer nuclear layer to photoreceptors, occasionally with a characteristic subretinal cleft.

CHPRE is a rapid, non-invasive and specific phenotypical marker for FAP. Multiple lesion number and bilateralism are CHRPE features with the greatest specificity for FAP. Combining ophthalmic assessment with endoscopy and genetic testing has the greatest accuracy when assessing at …

CHRPE has been reported in the absence of colonic polyposis but has been reported in up to 90% of patients with some variant of FAP and is a highly sensitive marker. The signature non-ocular feature of this syndrome is the occurrence of numerous, sometimes thousands, of gastrointestinal polyps located mainly in the colon.