Cholesterol 7 alpha-hydroxylase is a cytochrome P450 heme enzyme that oxidizes cholesterol in the position 7 using molecular oxygen. It is an oxidoreductase. CYP7A1 is located in the …

Your cholesterol levels show how much cholesterol is in your blood. Your HDL is the one number you want to be high (ideally above 60). Your LDL should be below 100.

A total cholesterol level of 7 mmol/L (271 mg/dL) is considered high. Although cholesterol has several essential roles in the body, high cholesterol puts you at greater risk for heart disease. …

Jun 1, 1993 · Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts …

Jun 1, 2020 · The classic pathway of bile acid synthesis from cholesterol is catalyzed by cholesterol 7 alpha-hydroxylase (CYP7A1). 7α-hydroxycholesterol is then converted to 7α …

Cholesterol oxidation products, especially 7-ketocholesterol (7KCh), are highly toxic and associated with chronic diseases including atherosclerotic and neurodegenerative processes …

The cholesterol 7 alpha-hydroxylase (CYP7A1) enzyme plays an important role in the conversion of cholesterol to bile acid, contributing to the reduction of cholesterol plasma levels in normal …

Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled …

Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the …

Cholesterol 7 alpha-hydroxylase (7 alpha-hydroxylase) is the rate-limiting enzyme in bile acid biosynthesis. It is subject to a feedback control, whereby high levels of bile acids suppress its …