In this Commentary, we discuss the mechanisms through which Cdk5 is regulated by binding to its protein partners in normal and diseased brains. In addition, we describe the mechanisms by which Cdk5 and p35 are regulated at transcriptional, …

Cdk5 is a proline-directed serine/threonine kinase, which was first identified as a CDK family member due to its similar structure to CDC2/CDK1 in humans, a protein that plays a crucial role in the regulation of the cell cycle.

CDK5 can be mapped to chromosome 7q36 and its expression is upregulated by the transcription factors Fos and CREB through the MEK/ERK pathway and by δFosB [11, 12]. CDK5 plays a vital role in the central nervous system but has functions in other cell types.

Apr 15, 2011 · CDK5 phosphorylation: High-fat diet (HFD) can promote cleavage of p35, producing p25, a CDK5 activator. CDK5 phosphorylation of PPARγ alters its transcriptional program, for example, having no effect on adipogenesis but decreasing expression of the antiinflammatory adipokine adiponectin.

Here, we highlight the regulatory mechanisms of CDK5 and its roles in cellular processes such as gene regulation, cell survival, and apoptosis. Keywords: CDK5, p25 phosphorylation, p35, p39, neural apoptosis. 1. Introduction.

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase that has been demonstrated to be one of the most functionally diverse kinases within neurons. Cdk5 is regulated via binding with its neuron-specific regulatory subunits, p35 or p39.

Oct 1, 2001 · Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system.

Jan 21, 2025 · CDK5 plays a crucial role in various physiological processes, and its dysfunction has been closely associated with the development of neurodegenerative diseases, metabolic disorders, psychiatric conditions, and cancer. This article provides a comprehensive review of CDK5’s roles and implications.

Mar 1, 2023 · Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly found in the brain and plays a significant role in developing the central nervous system. Recent evidence suggests that CDK5 is activated by specific cyclins regulating its expression and activity.

Dec 20, 2011 · Here, we summarize recent findings on the involvement of Cdk5 in the pathophysiological mechanisms underlying various neurodegenerative diseases. Cdk5 is a serine/threonine kinase that is activated upon association with its activator p35 or p39.