Cdk5 is a proline-directed serine/threonine kinase, which was first identified as a CDK family member due to its similar structure to CDC2/CDK1 in humans, a protein that plays a crucial …

Ckd5是作为一种多功能激酶，其主要功能是参与神经细胞迁移、轴突导向、突触发生与传递，近年来研究发现，CDK5在多种组织中表达，它可以通过磷酸化不同的调节底物发挥多种生物学作 …

Nov 6, 2019 · Treatment with the CDK5 inhibitor roscovitine sensitizes cells to heat-induced apoptosis and its phosphorylation, which results in prevention of the apoptotic protein …

Oct 1, 2001 · Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system.

Mar 30, 2025 · CDK5 (Cyclin Dependent Kinase 5) is a Protein Coding gene. Diseases associated with CDK5 include Lissencephaly 7 With Cerebellar Hypoplasia and Lissencephaly. Among its …

The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The …

Sep 4, 2024 · CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392.

Jan 21, 2025 · This review explores the structure and biological functions of CDK5, highlighting its regulatory roles in disease development through the phosphorylation of diverse substrate …

Mar 1, 2023 · CDK5 renders between the nucleus and cytoplasm during G₀/G₁ phase, where CDK5 stays in the nucleus with normal E2F1 transcription activity and blocks the exit of p27. …

The cyclin-dependent kinase 5 (CDK5) is known as an exceptional component of the CDK family, due to its characteristic regulatory pathways and its atypical roles in comparison to the …