Here we describe the structure of CD8αβ in complex with the murine MHCI molecule H-2D d at 2.6 Å resolution. The focus of the CD8αβ interaction is the acidic loop (residues 222-228) of …

Aug 15, 2009 · In this study we describe the structure of CD8αβ in complex with the murine MHCI molecule H-2D d at 2.6 Å resolution. The focus of the CD8αβ interaction is the acidic loop …

In this study, we used a panel of MHCI mutants with altered CD8-binding properties to show that TCR-mediated antigen specificity is delimited by a pMHCI/CD8 affinity threshold.

Aug 15, 2009 · In this study we describe the structure of CD8alphabeta in complex with the murine MHCI molecule H-2D(d) at 2.6 A resolution. The focus of the CD8alphabeta interaction …

Aug 3, 2023 · CD8 + cytolytic T cells have a central role in the efficacy of cancer immunotherapy. Classically, naive or antigen-experienced CD8 + T cells recognize and react to tumor …

Aug 3, 2023 · Here, we report that CD8 + T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression. This capacity proves to be dependent instead on …

Jul 15, 2011 · The CD8 glycoprotein, which serves as the coreceptor on MHCI-restricted T cells, acts to enhance the Ag sensitivity of CD8 + T cells by binding to a largely invariant region of …

Jun 15, 2020 · Naive CD8 + T cell survival in the periphery is critically dependent on tonic TCR signaling through peptide + MHC class I (MHCI) recognition; however, little is known about …

Mouse CD8ab can form two different complexes with pMHCI via either the CD8a- or CD8b-dominated interaction. To understand the functional significance of these complexes in vivo, …

Sep 24, 2001 · CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of …