transfer experiments in T-cell hybridomas (4, 5) have shown coreceptor CD8a extracellular region, CDSal61, and that CD8 is the amino-terminal immunoglobulin-like domain, CDSall4, in …

A soluble form of the rat CD8 alpha chain was produced by introducing a stop codon into the cDNA at the end of the region encoding the extracellular sequence and expressed in Chinese …

We outline the unique structure and function of different CD8 domains (ectodomain, hinge, transmembrane, cytoplasmic tail) in the context of the distinct properties of CD8αα …

In CD8αα dimers, it pairs with C181 of another CD8A monomer, while in CD8αβ dimers, it pairs with C168 of CD8B. Cysteine residues in the transmembrane helix (TMH) of CD8A also play …

Mar 28, 2025 · CD8A (CD8 Subunit Alpha) is a Protein Coding gene. Diseases associated with CD8A include Immunodeficiency 116 and Hemolytic Uremic Syndrome, Atypical 6. Among its …

CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of …

Apr 23, 2023 · CD8A can be a novel candidate biomarker for BPD, which plays an essential role in the onset and progress of hyperoxia-related BPD via the disruption of immune cell functions. …

encoded by two distinct genes: CD8a (Lyt2) and CD8b The crystal structure of the two immunoglobulin vari- ( Lyt3 ) (DiSanto et al., 1988; Norment and Littman, 1988, able–like …

Dec 15, 1993 · In these conditions, less CD8a co-precipitated with CDSp, presumably due to instability of the noncovalent ap dimer during lysis and immunoprecipitation. Thus, the …

Feb 15, 2008 · On CD8αβ + T cells, the induced transcription of Cd8a results in the coexpression of CD8αα with CD8αβ (Madakamutil et al., 2004). The differential expression of CD8αα and …