T-cell surface glycoprotein CD8 alpha chain (C luster of D ifferentiation 8a), is a protein encoded by CD8A gene. [5] The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell - antigen interactions.

Mar 28, 2025 · CD8A (CD8 Subunit Alpha) is a Protein Coding gene. Diseases associated with CD8A include Immunodeficiency 116 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are TCR Signaling (Qiagen) and Network map …

Feb 8, 2025 · Title: Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and Beckwith-Wiedemann Syndrome (BWS). Induced CD8alpha identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation.

Gene ID: 925, updated on 8-Feb-2025. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.

Sep 17, 2024 · Clinical resource with information about CD8A, Susceptibility to respiratory infections associated with CD8alpha chain mutation, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

3 days ago · High expression of CD8A and PGF were associated with favorable and poor prognosis in gastric cancer patients, respectively. Immunoinfiltration analysis revealed a positive correlation between CD8A and dendritic cell (DC) levels, while a negative correlation was observed with myeloid-derived suppressor cell (MDSC) levels.

CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers.

Apr 1, 2002 · These two papers provide compelling evidence that the CD8αα homodimer and CD8αβ heterodimer are truly different in their functions, at least in mice. It is noteworthy that a TL homologue has not been found in humans, and so the question remains as to whether these findings apply to human CD8. 1. Moody, A.M ...

CD8A is a novel indicator for predicting the prognosis and immunotherapeutic response in BCa. A radiomics signature has the potential to preoperatively predict the expression of CD8A in BCa patients. Keywords: bladder cancer, CD8A, MRI, radiogenomics, immunotherapy, prognosis. 1. …