Nov 15, 2022 · CD84 antigen is an immunoreceptor member of the SLAM family (SLAMF5), whose expression has been reported in certain immune cells and in B-cell malignancies. In this study, we show for the first time that CD84 is overexpressed in AML and present the first results of CD84-targeting CAR T-cells for the treatment of this disease.

CD84-mediated signaling regulates diverse immunological processes, including T cell cytokine secretion, natural killer cell cytotoxicity, monocyte activation, autophagy, cognate T:B interactions, and B cell tolerance at the germinal center checkpoint.

Aims: Validating CD84 as a target for haematological malignancies, in concrete, for acute myeloid leukaemia (AML) and T-cell acute lymphoblastic leukaemia (T-ALL). Engineer a first-in-class CD84-targeted CAR T-cell therapy (CART84) for the …

Here, we show that the levels of CD84, a SLAM family receptor, increase in T and B cells in lung tissues from M. tuberculosis -infected C57BL/6 mice and in peripheral blood mononuclear cells (PBMCs) from pulmonary TB patients.

Nov 15, 2022 · With the goal of developing a novel and highly specific CAR-T cell approach for pediatric AML, we performed a large analysis of a gene expression dataset from AML patients and identified for the first time the CD84 as an AML specific antigen.

Sep 25, 2020 · In vitro, platelet-derived soluble CD84 enhanced motility of wild-type but not of Cd84-/-CD4 + T cells suggesting homophilic CD84 interactions to drive this process. Clinically, human arterial blood directly sampled from the ischemic cerebral circulation indicated local shedding of platelet CD84.

Oct 2, 2018 · We showed that cell-cell interaction mediated through human and mouse CD84 upregulates PD-L1 expression on CLL cells and in their microenvironment and PD-1 expression on T cells. This resulted in suppression of T cell responses and activity in vitro and in vivo.

Dec 3, 2018 · We showed that cell-cell interaction mediated through human and mouse CD84 upregulates PD-L1 expression on CLL cells and in their microenvironment and PD-1 expression on T cells. This resulted in suppression of T cell responses and activity in vitro and in vivo.

CD84 (C luster of D ifferentiation 84) is a human protein encoded by the CD84 gene. [5] Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells. [5]

Jul 1, 2019 · CD84-mediated signaling regulates diverse immunological processes, including T cell cytokine secretion, natural killer cell cytotoxicity, monocyte activation, autophagy, cognate T:B interactions, and B cell tolerance at the germinal center checkpoint.