Mar 26, 2004 · Here we report that the cytoplasmic domain of CD43 contains a functional bipartite NLS that can translocate it into the nucleus. Replacement of the basic amino acids in both clusters of the NLS in CD43ct inhibited the nuclear localization.

Mar 26, 2004 · Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with beta-catenin and causes an upregulation of the …

Here we provide evidence that the CD43 sialomucin cooperates with oncogenic signals to promote cell transformation by abrogating the contact inhibition of growth through a molecular mechanism that involves AKT-dependent Merlin phosphorylation and degradation.

Jan 1, 2018 · CD43 is a bulky and extended cell surface mucin that protrudes 45 nm from the cell surface. Its 239-amino acid-long extracellular domain comprises five tandem repeats of 18 amino acids each (116 Ile– 205 Ser), rich in serines and threonines modified by O-GalNAc glycosylation.

Apr 4, 2005 · Recently, we found that CD43 contains a functional NLS (nuclear localization signal) sequence in the intracellular domain, translocating it to the nucleus. In the nucleus, the cytoplasmic tail of CD43 was found to interact with β-catenin, and was shown to affect genes regulated by β-catenin/TCF-4-responsive promoters [ 19 ].

Sep 24, 2007 · Here, we show that overexpression of CD43 increases cell growth and colony formation in mouse and human cells lacking expression of either p53 or ARF (alternative reading frame) tumor-suppressor...

Sep 5, 2008 · The proposed functional NLS for CD43 is shown on the top of the alignment. Part of the nonpolar region of CD43 forms a short β-strand (residues 8–11) in our FERM–CD43 complex. Of the 20 residues of the CD43 peptide, 15 residues (4–18) …

CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia.

Mar 19, 2024 · Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)

Mar 26, 2004 · Here we report that the cytoplasmic domain of CD43 contains a functional bipartite NLS that can translocate it into the nucleus. Replacement of the basic amino acids in both clusters of the NLS in CD43ct inhibited the nuclear localization.