CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils [6] and neutrophil precursors from the myelocyte stage onwards.

Mar 30, 2025 · CD24 (CD24 Molecule) is a Protein Coding gene. Diseases associated with CD24 include Erythroleukemia and Multiple Sclerosis. Among its related pathways are Nervous system development and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and carbohydrate binding.

We demonstrate a role for tumour-expressed CD24 in promoting immune evasion through its interaction with the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which is expressed by tumour-associated macrophages.

Feb 15, 2010 · In the adaptive immune response, CD24 is a redundant costimulatory molecule in costimulation-rich lymphoid organs but is essential in selected target organs tested, such as brain and skin. More...

Aug 12, 2019 · A new study now reports that one such ‘don’t eat me’ signal, CD24, orchestrates a novel innate immune checkpoint through interaction with the inhibitory receptor sialic acid-binding...

CD24 has been identified as a promising target for cancer immunotherapy, and targeting it with antibody drugs could offer effective treatment options. This review builds on existing research on CD24, exploring its structure and role in cancer, with a focus on current studies of antibody drugs targeting the protein and potential treatments.

Exosomes carrying CD24, named EXO-CD24, combine advantages of both exosomes as a novel drug delivery platform and CD24 as a potent immune checkpoint surveillance molecule.

In the adaptive immune response, CD24 is a redundant costimulatory molecule in costimulation-rich lymphoid organs but is essential in selected target organs tested, such as brain and skin. More recent studies suggest it may have a role in discriminating danger and pathogen-associated molecular patterns by dendritic cells.

In preclinical studies, CD24 target therapies, including monoclonal antibodies, target silencing by RNA interference and immunotherapy, have shown us brighten futures on the anti-tumor application. Nevertheless, evidences based on clinical studies are urgently needed.

Recent studies demonstrate that CD24 controls an important genetic checkpoint for homeostasis and autoimmune diseases in both mice and humans. Understanding the molecular and cellular basis of CD24 function could provide important insights into T cell biology and autoimmunity.