CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family.

The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4 + T cells, CD8 + T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and also at a high level by endothelial cells.

Mar 28, 2025 · CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include Cytomegalovirus Retinitis and Acquired Immunodeficiency Syndrome . Among its related pathways are Response to elevated platelet cytosolic …

Feb 8, 2025 · Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells. Podergajs N, et al. Oncotarget, 2016 Jan 5. PMID 26573230, Free PMC Article. CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells. Nishida H, et al. Biochem Biophys Res Commun, 2009 Apr 24. PMID 19254692

Mar 15, 2022 · Also called tetraspanin CD9, motility related protein 1 (MRP1) [note: MRP is multidrug resistance associated protein] Antibodies are used to purge bone marrow in acute lymphoblastic leukemia prior to peripheral stem cell bone marrow transplant ( Am J Pediatr Hematol Oncol 1993;15:162 )

Apr 30, 2018 · The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4 + T cells, CD8 + T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and also at a high level by endothelial cells.

Apr 28, 2020 · CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection. CD9 is...

Genomic organisation of the CD9 gene on chromosome 12. The gene spans 38 kb of DNA, including a 10 kb intron separating the first two exons. CD9 encodes 8 exons, ranging from 63 to 109 base pairs. The coding sequence is highly conserved between species.

May 1, 2023 · CD9, a tetraspanin, has been shown to accumulate on CD4 T cells at the immunological synapse, playing a role in co-stimulation and stabilization of the synapse via regulation of the integrins LFA-1 and VLA-4.

Jun 24, 2024 · CD9 is a versatile protein that plays critical roles in cell adhesion, signaling, and membrane organization. Its involvement in health and disease underscores its importance in cellular function and clinical research.