CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.

CD8 deficiency is an extremely rare autosomal recessive disorder due to homozygous variants in the CD8A gene. CD8 is a T cell receptor (TCR) accessory molecule that interacts with the major histocompatibility complex (MHC). CD8 is found on cytotoxic T cells and NK cells.

Resting naive CD8 + T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body to clear the infection.

Mar 20, 2025 · Explore the role of CD8 activation markers in T-cell function, their expression across tissues, and methods for assessing immune responses in different contexts. CD8 T cells play a crucial role in immune defense by identifying and eliminating infected or malignant cells.

Jan 15, 2025 · CD8 is a surface glycoprotein predominantly expressed on cytotoxic T-cells, a specialized subset of T-cells tasked with directly eliminating infected or malignant cells. Unlike CD4, CD8 binds to MHC class I molecules, which are present on nearly all nucleated cells.

Cytotoxic CD8 + T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8 + T cell metabolism is coupled to transcriptional, translational and epigenetic changes that …

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...

T-cell surface glycoprotein CD8 alpha chain (C luster of D ifferentiation 8a), is a protein encoded by CD8A gene. [5] The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.

In this review, we discuss the utility of CD8 in relation to its immunomodulatory properties. We outline the unique structure and function of different CD8 domains (ectodomain, hinge, transmembrane, cytoplasmic tail) in the context of the distinct properties of CD8αα homodimers and CD8αβ heterodimers.

Aug 24, 2023 · Both the CD8 antigen (acting as a coreceptor) and the T cell receptor recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules; CD8 binds to non-polymorphic region of class I molecules; may increase avidity of interactions between cytotoxic T cell and target cell during antigen-specific activation