CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes [6] through binding to the receptors CCR1, CCR4 and CCR5. [5]

Mar 30, 2025 · CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Aseptic Meningitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

Macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) is a chemotactic chemokine secreted by macrophages. It performs various biological functions, such as recruiting inflammatory cells, wound healing, inhibition of stem cells, and maintaining ...

either the CCL3 gene may play a significant role in CCL3 production and/or that as yet undefined mechanisms regulate production of CCL3 from variable CCL3L copy number. High serum CCL-3 is associated with disease severity of generalized pustular psoriasis.

CCL3 or macrophage inflammatory protein-1α (MIP-1α), an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies.

Van Emmenis, Mòdol-Caballero, and colleagues have identified CCL3 as a Schwann cell chemotactic factor secreted by hypoxic macrophages that is essential for guiding axons during peripheral nerve regeneration.

CCL3, also known as macrophage inflammatory protein 1α (MIP-1α), induces inflammatory cytokines to specific sites by binding to the CCR1/3/9 receptors (Li et al., 2020). CCL3 is mainly produced by mononuclear macrophages, lymphocytes, and neutrophils, but can also be produced by …

Oct 2, 2018 · In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population, and leukemia progression. With CCL3 implicated as a potentially...

CCL3, also known as macrophage inflammatory protein-1 alpha (MIP-1α), is a type of chemokine that plays a vital role in immune responses by recruiting immune cells, particularly monocytes and T cells, to sites of inflammation.

ccl3 A gene on chromosome 17q12 that encodes a small inducible cytokine, commonly known as macrophage inflammatory protein 1 (MIP-1) alpha, which is produced by CD8+ T cells and is a major HIV-suppressive factor.