Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays …

The described roles of caspase-7 in apoptosis and inflammation suggest that interfering with caspase-7 activation may prove beneficial in conditions where excessive cell death and/or …

Mar 30, 2025 · CASP7 (Caspase 7) is a Protein Coding gene. Diseases associated with CASP7 include Cataract and Type 1 Diabetes Mellitus 17. Among its related pathways are TNFR1 …

Caspases (c ysteine- asp artic prote ases, c ysteine asp art ases or c ysteine-dependent asp artate-directed prote ases) are a family of protease enzymes playing essential roles in …

Together with caspase-3 and -6, caspase-7 belongs to the subgroup of executioner caspases (Lamkanfi et al., 2002). It was originally cloned as ICE-LAP3, Mch3 and CMH-1 by three …

Caspase-9 can cleave and activate Bid, caspase-7 and caspase-3. tBid can remodel the mitochondria and make conditions favorable for ROS production, which is enhanced by …

Feb 8, 2025 · caspase-7 is involved earlier than other effector caspases in apoptosis; Collectively, these data suggest that cathepsin D activation of caspase 3/7 may be required for inducing …

We show that the N-peptide of caspase-7 plays no role in the fundamental activation or properties of the active protease in vitro. However, the N-peptide modifies the properties of caspase-7 in …

Oct 1, 2009 · The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and-7 during TGEV-induced apoptosis. J. Virol. 2000; 74:3975–3983. …

Caspase-7 Antibody detects endogenous levels of both full length caspase-7 (35 kDa) and the large fragment of cleaved caspase-7 following cleavage at aspartic acid 198 (20 kDa). The …