Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. [5][6][7] Orthologs of this gene also exist in other mammals, such as sirenians and cetaceans, though they are inactivated in these two clades.

Caspase-14 is a unique member of the caspase family—a family of molecules participating in apoptosis. However, it does not affect this process but regulates another form of programmed cell death—cornification, which is characteristic of the ...

Caspase-14 is a unique member of the evolutionarily conserved family of cysteinyl aspartate–specific proteinases, which are mainly involved in inflammation and apoptosis. However, recent evidence also implicates these proteases in proliferation and differentiation.

Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years.

Mar 30, 2025 · CASP14 (Caspase 14) is a Protein Coding gene. Diseases associated with CASP14 include Ichthyosis, Congenital, Autosomal Recessive 12 and Ichthyosis. Among its related pathways are Differentiation of keratinocytes in interfollicular epidermis in mammalian skin and Keratinization.

Feb 9, 2025 · High CASP14 expression is a marker of breast cancer aggressiveness in association with proliferation, TNBC phenotype, and cancer stemness. Title: Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.

Denecker et al. show that caspase-14 controls the maturation of the epidermis by proteolytically processing filaggrin. The ultimate products of this cleavage prevent UVB photodamage and water...

Jul 24, 2001 · Caspase-14 is a newer member of the caspase family, and was identified independently by three groups, 5, 6, 7 two of which suggested that caspase-14 may be skin specific.

Here we report a novel developmentally regulated short prodomain caspase designated MICE or caspase-14 that is a member of the caspase-1 subfamily and possesses unique biochemical properties.

May 25, 2021 · Caspase-14 is a unique member of the caspase family-a family of molecules participating in apoptosis. However, it does not affect this process but regulates another form of programmed cell death-cornification, which is characteristic of the epidermis.