Probiotic-guided CAR-T cells for solid tumor targeting | Science
Oct 12, 2023 · To bridge these approaches, we developed a platform of probiotic-guided CAR-T cells (ProCARs), in which tumor-colonizing probiotics release synthetic targets that label tumor …
Enhanced CAR-T activity against established tumors by ... - Nature
Nov 19, 2020 · Here, we demonstrate that human CAR-T cells polarized and expanded under a Th9-culture condition (T9 CAR-T) have an enhanced antitumor activity against established …
Novel high‐affinity EGFRvIII‐specific chimeric antigen receptor T …
We have made novel chimeric antigen receptor T (CART) cells specific for glioblastoma, a devastating brain tumor with poor survival. This receptor is of extremely high affinity, and the …
CAR T cell killing requires the IFNγR pathway in solid but ... - Nature
Apr 13, 2022 · CAR T cells targeted an endogenous, homogeneously expressed surface antigen, epidermal growth factor receptor (EGFR).
Anti-tumor Efficacy of CD19 CAR-T in a Raji B Cell Xenografted …
Chimeric antigen receptor (CAR)-T therapy launched a new era for cancer treatments, displaying outstanding effectiveness in relapsed or refractory B-cell malignancies. Demonstrating the …
Engineering Efficient CAR-T Cells via Electroactive Nanoinjection
When compared to BEP, the ENI platform achieved an almost threefold higher CAR transfection efficiency, indicated by the significantly higher expression of reporter GFP (43.3% in ENI …
Inducible expression of interleukin-12 augments the efficacy of ...
Apr 12, 2023 · Although affinity-tuned CARs showed suboptimal antitumor activity in vivo, we found that inducible secretion of interleukin-12 (IL-12), under the control of the NFAT …
CART neurons in the arcuate nucleus and lateral hypothalamic …
The conditional tamoxifen-induced Cre activation and concomitant intranuclear delivery of AAV-FLEX-Cart or AAV-FLEX-GFP in the hypothalamus resulted in Cart cre/cre and Cart cre/+ …
APOBEC3B expression in 293T viral producer cells drives mutations …
Dec 19, 2024 · Chimeric antigen receptor (CAR) T cells are a clinically approved therapy for blood cancers. To produce clinical-grade CAR T cells, a retroviral or lentiviral vector is used to …
Size-dependent activation of CAR-T cells | Science Immunology
Aug 5, 2022 · The CAR used in this study was composed of an scFv-recognizing CD19 (FMC63), a stalk and transmembrane domain from CD8α, and a cytosolic part containing tandem …