Calnexin is a chaperone, characterized by assisting protein folding and quality control, ensuring that only properly folded and assembled proteins proceed further along the secretory pathway. …

Calnexin is a type I integral endoplasmic reticulum (ER) membrane protein with an N-terminal domain that resides in the lumen of the ER and a C-terminal domain that extends into the …

Apr 27, 2022 · In the calnexin cycle, proteins carrying monoglucosylated glycans bind to the lectin chaperones calnexin and calreticulin, which recruit a variety of function‐specific chaperones to …

In this chapter we present the evidence that calnexin (CNX) and calreticulin (CRT) function as molecular chaperones to assist in the folding and subunit assembly of the majority of Asn …

Jul 1, 2016 · Calnexin gene-silencing significantly reduced cell survival and increased cancer cell susceptibility to 5FU chemotherapy. Conclusion: Increased tumour protein levels of calnexin …

In the present study, we significantly expand on the key role of calnexin in colon cancer cell survival by demonstrating that gene silencing of calnexin decreases clonogenic cell survival.

Calreticulin (CRT) and calnexin (CNX) are members of a family of endoplasmic reticulum (ER) chaperones that fold newly synthesized polypeptides. Aside from their role as foldases in the …

Calnexin is a new type of molecular chaperone that interacts with many nascent membrane and soluble proteins of the secretory pathway. Calnexin is unrelated to molecular chaperones of …

Gutiérrez et al. investigated the role of calnexin, an ER chaperone that interacts with SERCA, the ATPase that pumps Ca 2+ into the ER, in mitochondrial bioenergetics. The authors found that …

Oct 21, 2022 · Calnexin is a ubiquitously expressed molecular lectin-like chaperone. Together with calreticulin (CALR; 109091), calnexin promotes folding of glycosylated proteins in the …