Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body.

CYP3A4 and CYP3A5 genetic polymorphisms and abnormal drug metabolism. CYP3A4 can form oligomers in the cell, but its basic functional unit is a single polypeptide with a large active site capable of binding multiple substrates simultaneously, contributing to …

Dec 16, 2015 · It has been estimated that CYP3A4 metabolizes about half of all drugs on the market. Since many other commonly used drugs are moderate to potent inhibitors of CYP3A4, it is not surprising that the drug toxicity of CYP3A4 substrates, due to inhi- bition of CYP3A4, is relatively common.

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous ...

CYP3A4 is the major hepatic CYP3A enzyme and is also present in the intestinal epithelium. CYP3A4 activity shows wide inter-individual variation of up to 40-fold. 14. The first genetic CYP3A4 polymorphism described is the promoter variant allele CYP3A4∗1B (A-392G) with a large interethnic variation. The allele frequency is 2–9% in ...

Sep 9, 2021 · CYP3A4 is an important CYP enzyme, responsible for clearing approximately 45 – 60% of currently prescribed drugs. Different supplements, food components, and drugs can change CYP3A4 activity and, as a result, interfere with drug metabolism. Find out more about its function, gene variants, and factors that decrease/increase CYP3A4 activity.

Mar 28, 2025 · CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) is a Protein Coding gene. Diseases associated with CYP3A4 include Vitamin D-Dependent Rickets, Type 3 and Acetaminophen Metabolism. Among its related pathways are Clomipramine Pathway, Pharmacokinetics and Metapathway biotransformation Phase I and II.

Mar 26, 2025 · The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients. Elens L, et al. Pharmacogenet Genomics, 2012 May. PMID 22388796; See all (965) citations in PubMed

Dec 5, 2024 · This article first reviews the role of CYP3A4/5 in drug metabolism in the human body, including inhibitors and inducers of CYP3A4/5 and drug-drug interactions. In terms of genetic polymorphism, it discusses the detection methods, enzymatic kinetic characteristics, and clinical guidelines for CYP3A5.

Feb 27, 2025 · What is CYP3A4 and Its Role in Drug Metabolism. CYP3A4 is an enzyme belonging to the cytochrome P450 superfamily. Collectively, these enzymes play a vital role in metabolizing a majority of medications. CYP3A4 is primarily found in the liver and small intestine. This enzyme assists in breaking down and eliminating a variety of drugs from the body.