Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). The CXCL9 is one of the chemokine which plays role to induce chemotaxis, promote differentiation and multiplication of leukocytes, and cause tissue extravasation. [5]

030285 B6.129S4- Cxcl9 tm1Jmf /J These Cxcl9 knock-out mice exhibit increased susceptibility to viral and intracellular parasite infection, and reduced antibody production in response to bacterial infection.

Feb 8, 2025 · CXCL9 has a role in graft rejection in the absence of CCL19 and CCL21; CXCL9 is up-regulated in unique patterns following tracheal transplantation in mice. Deletion of CXCL9 does not affect airway obliteration.

CXCL9 is also associated with human hepatic fibrosis and anti‐fibrosis in mice 23, 24. Fos‐related antigen 1 (Fra‐1) represses CXCL9 expression by direct promoter binding in hepatocytes and affects the fibrotic response to some extent 25.

CXCL9, also known as monokine induced by gamma interferon (MIG), is located on human chromosome 4, and is induced by IFN-γ but not by IFN-α/β. CXCL10 and CXCL11 are also located on human chromosome 4. CXCL9 predominantly mediates lymphocytic infiltration to the focal sites and suppresses tumor growth.

Mar 18, 2025 · Mice homozygous for a knock-out allele show a significant reduction in CD4+ T cell infiltration into the cornea in response to ocular HSV-1 infection, and produce lower titers of antibodies in response to primary infection with the intracellular bacterium Francisella tularensis live vaccine strain.

Jan 13, 2025 · Study in human cervical epithelial cells and mouse model highlights Herpes simplex virus type 2 (HSV-2) ICP4 as a vital viral protein in promoting CXCR3 ligand expression and CXCL9 as the key induced chemokine in mediating CD4+ T cell migration in HSV-2 infection.

CXCL9 has been shown to be a chemoattractant for activated T-lymphocytes and TIL but not for neutrophils or monocytes. The mouse CXCL9 cDNA encodes a 126 amino acid residue precursor protein with a 21 amino acid residue signal peptide that is cleaved to yield a 105 amino acid residue mature protein.

Jul 13, 2024 · In this study, we uncovered a previously uncharacterized role of monocyte-originated CXCL9/10 in regulation of bactericidal function of neutrophils and macrophages in vitro and at an acute stage of S. aureus osteomyelitis in mice.

Mar 30, 2025 · CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Proliferative Glomerulonephritis and Paracoccidioidomycosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation …