Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha …

Jun 21, 2018 · Deposition of CXCL4 onto the vascular endothelium is involved in atherosclerosis, facilitating monocyte arrest and recruitment by an as yet, unidentified receptor. Here, we …

Jul 1, 2023 · CXCL4, called as platelet factor 4, is a small protein released from activated platelets. It exerts many functions like hemostasis and stimulation of immune cells at site of …

Platelet factor 4 (CXCL4) is a chemokine abundantly stored in platelets. Upon injury and during atherosclerosis, CXCL4 is transported through the vessel wall where it modulates the function …

Thus, we wondered whether: (1) CXCL4 in HSPCs is an initiator of the fibrotic transformation; (2) CXCL4 expression in stromal cells is a marker for fibrosis progression; and (3) CXCL4 plays a …

May 1, 2019 · Here, we elucidate an unanticipated mechanism for CXCL4-mediated immune amplification in SSc, in which CXCL4 organizes “self” and microbial DNA into liquid crystalline …

The platelet-derived chemokine CXCL4 takes a specific and unique position within the family of chemotactic cytokines. Today, much attention is directed to CXCL4's capacity to inhibit …

Jun 21, 2018 · Activated platelets release micromolar concentrations of the chemokine CXCL4/Platelet Factor-4. Deposition of CXCL4 onto the vascular endothelium is involved in …

Sep 17, 2020 · Our study unveils that CXCL4 acts as a key secreted factor driving innate immune training and forming the long-sought link between inflammation and fibrosis. Keywords: …

CXCL4/Platelet Factor-4 was the first member of the chemokine family to be discovered 8 and is found at significant levels in atherosclerotic plaques, where its abundance correlates with …