Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin -like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2.

Mar 30, 2025 · CXCL16 (C-X-C Motif Chemokine Ligand 16) is a Protein Coding gene. Diseases associated with CXCL16 include Systemic Scleroderma and Covid-19. Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling.

CXCL16 is a chemokine that is expressed on the surface of certain immune cells and is involved in attracting activated T-lymphocytes during inflammation, facilitating immune responses, and guiding T-cell movement in the spleen. Its exact biological role is not yet fully understood. You might find these chapters and articles relevant to this topic.

Mar 28, 2021 · CXCL16 is a chemotactic cytokine belonging to the α-chemokine subfamily. It plays a significant role in the progression of cancer, as well as the course of atherosclerosis, renal fibrosis, and non-alcoholic fatty liver disease (NAFLD).

Screening for 37 chemokines in prostate cancer cell lines and xenografts revealed CXCL16, the ligand for the receptor CXCR6, as the most consistently expressed chemokine.

May 15, 2024 · Islet macrophages highly expressed CXCL16, a chemokine and scavenger receptor for oxidized low-density lipoproteins (OxLDLs), regardless of autoimmune predisposition. Deletion of Cxcl16 in nonobese diabetic (NOD) mice suppressed the development of …

Oct 10, 2016 · CXCL16 is a chemokine normally expressed in the brain, where it exerts neuroprotective activity against glutamate-induced damages through cross communication with astrocytes and the involvement...

Feb 8, 2025 · CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways. C-X-C motif chemokine 16, modulated by microRNA-545, aggravates myocardial damage and affects the inflammatory responses in myocardial infarction.

Aug 1, 2023 · CXCL16 is expressed in various immune cells, such as dendritic cells, monocytes, macrophages, and B cells. During autoimmune diseases, CXCL16 can facilitate the adhesion of immune cells like monocytes, T cells, NKT cells, and others to endothelial cells and dendritic cells.

Sep 23, 2013 · CXCL16 is a recently discovered cytokine belonging to the CXC chemokine family and is unique in that it combines scavenger receptor functions with properties of an inflammatory chemokine. It exists in a transmembrane and soluble form.