Ctla-4 KO T cells develop more Th2 cells after CD3/CD28 stimulation than WT T cells, and CTLA-4-Ig treatment improves the mouse survival rate by reducing T-cell activation and proliferation (Khattri et al., 1999).

Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses.

We abrogated CTLA-4 expression in adult mice and compared their phenotype with congenitally CTLA-4–deleted mice. We found that the two modes of CTLA-4 deficiency differed in resulting autoimmune disease phenotype and severity.

Feb 15, 2021 · We found that CTLA-4 blockade promotes metabolic fitness and the infiltration of immune cells, especially in glycolysis-low tumours. Accordingly, treatment with anti-CTLA-4 antibodies improved...

Feb 8, 2025 · CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice. CTLA-4 inhibition facilitates follicular T and B cell interaction and the production of tumor-specific antibodies. CTLA-4 on thymic epithelial cells complements Aire for T …

The 9D9 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. CTLA-4 …

Jan 24, 2025 · The antibody 9D9, which binds mouse CTLA-4, is a commonly used surrogate for CTLA-4 checkpoint blockade studies in mouse cancer models. In this work, we reveal that 9D9 has significant biophysical dissimilarities to therapeutic CTLA-4 antibodies.

Mar 31, 2025 · The serum sCTLA-4 levels are reportedly correlated with the frequency of lung metastasis in a mouse melanoma model. 11 In addition, sCTLA-4-secreting effector Treg cells are abundant in tumor tissues, hindering effective tumor immunity in humans and mice. 89 It is therefore likely that the anti-CTLA-4 antibody ipilimumab possesses three effects ...

Feb 22, 2018 · In Ctla4h/m mice expressing both human and mouse CTLA4 genes, anti-CTLA-4 antibodies that bind to human but not mouse CTLA-4 efficiently induce Treg depletion and Fc receptor-dependent...

Jan 4, 2018 · Evidence from knockout mice demonstrates a more severe phenotype in complete CTLA-4 knockouts compared with Treg-specific knockouts, indicating an important role for CTLA-4 in conventional T cells. 72 However, the function of CTLA-4 in non-Tregs can also be cell extrinsic, suggesting they might use the same mechanism as Treg, 74,75 and ...