Feb 22, 2021 · We found peptidylprolyl isomerase A (PPIA), a central enzyme in the protein-folding response pathway, as a potential new target for resistant MM. CRISPR–Cas9 deletion of PPIA or inhibition...

Casa Pia Atlético Clube, commonly known as Casa Pia, is a Portuguese multi-sports club founded in 1920 and based in Lisbon, Portugal, best known for its professional football team, that competes in the Primeira Liga.

Jun 3, 2024 · Ablation of PPIA promotes NRF2 protein degradation and blocks NRF2-driven growth in NSCLC cells. Mechanistically, PPIA physically binds to NRF2 and blocks the access of ubiquitin/Kelch Like ECH...

Jan 10, 2017 · Sanglifehrin A (SFA) is a mixed polyketide and non-ribosomal peptide synthase natural product with sub-nano-molar affinity for its receptor cyclophilin A (PPIA). It has been shown to behave in vitro as an immune suppressant.

Feb 2, 2017 · Cyclophilin A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), is an enzyme acting as an acceleration factor in protein folding and assembly and is the main target of the immunosuppressive drug cyclosporine A (CsA) (Fischer et …

Dec 9, 2013 · In certain nonhuman primate cells, the HIV-1 capsid protein (CA)-CYPA interaction is essential for restriction: HIV-1 infectivity is increased greater than 100-fold by cyclosporin A, a competitive inhibitor of the interaction, or by an HIV-1 CA mutation that disrupts CYPA binding.

Cyclosporin A (CsA) and the derivatives cyclosporin C, D, and H were screened against all PPIase domains except for PPIL3 and PPIL4, for which all constructs were insoluble or unstable in our hands .

Jan 1, 2011 · Cyclophilin A (CyPA; encoded by Ppia) is a ubiquitously expressed protein secreted in response to inflammatory stimuli. CyPA stimulates vascular smooth muscle cell migration and proliferation, endothelial cell adhesion molecule expression, and inflammatory cell chemotaxis.

Jan 15, 2022 · As an intracellular target of the immunosuppressive drug cyclosporin A (CsA) or a peptidyl-prolyl cis/trans isomerase (PPIase), it catalyzes the cis-trans isomerization of proline amidic peptide bonds, throug …

The Casa Pia child sexual abuse scandal was a case of child sexual abuses involving a number of children and employees at Casa Pia, a Portuguese state-run institution for the education and support of poor children and under-age orphans. [1] One employee of the institution, which at the time comprised 10 orphanages and schools caring for 4,600 children, ran a …