CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3. [5][6] CBP has intrinsic acetyltransferase functions; it is able to add acetyl groups to both transcription factors as well as histone lysines ...

The CREB (cyclic adenosine monophosphate (cAMP) response element-binding protein) Binding Protein (CBP), is a protein encoded by the CREBBP gene. CBP is a bromodomain-containing protein which emphasises its functionality in identifying acetylated lysine in histone proteins while also acting as effectors in signal associated with acetylation [1].

CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure.

The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also called EP300 or E1A binding protein p300) CBP (also known as CREB-binding protein or CREBBP)

Apr 28, 2020 · Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients.

Mar 30, 2025 · First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition.

Aug 1, 2001 · The structure of CREB complexed with its co-activator the CREB-binding protein (CBP) has provided new insights into potential mechanisms underlying signal discrimination.

The CREB binding protein (CBP) was first identified as a protein that specifically binds to the active phosphorylated form of the cyclic-AMP response element binding protein (CREB).

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription …

Apr 8, 2025 · Here we set out to explore the role of CREB-binding protein (CBP), a histone acetyltransferase (HAT), in DNA damage response, particularly in the ATM activation pathway. In response to DNA damage, CBP is stabilized and is recruited at sites of DNA double-strand breaks where it acetylates ATM and promotes its kinase activity.