Cre-Lox recombination is a site-specific recombinase technology, used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus.

A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre- loxP system and a few commonly used promoters for expression of tissue-specific Cre recombinase.

Unlock the power of the Cre/lox system for tissue-specific, inducible knockouts and advanced gene tracking in mouse models. Learn practical breeding schemes to simplify complexity, refine gene expression control, and avoid lethal phenotypes.

Cre activity is restricted to adult striated muscle fibers and embryonic striated muscle cells of the somites and heart. Transgenic cre activity, directed by the mouse aquaporin 2 promoter, is …

Here we describe how tamoxifen-dependent Cre recombinases, so-called CreER recombinases, work and how they can be used to generate time- and tissue-specific mouse mutants. The focus will be on the CreER (T2) recombinase, which is currently the most successful CreER version.

Cre mice, also known as Cre- loxP mice, are genetically modified mice that have become an essential tool in biomedical research. These mice have been instrumental in understanding the functions of specific genes in various biological processes.

There are over 480 Cre-recombinase expressing strains that are available from the JAX® Mice repository alone. With so many choices, how can you decide which Cre strain will generate the right KO model for you?

We review the current state of skeletal Cre driver lines, and highlight some of the successes, failures, and opportunities to improve fidelity in the skeleton, based on successes pioneered in other areas of biomedical science. Keywords: Cre, …

Over the past few years many inducible and/or tissue-specific Cre mouse lines have been developed. This chapter will give a brief review of the generation of Cre-expressing mouse lines and will discuss the strategy of using these Cre lines.

Cre is currently the most commonly used recombinase. It catalyzes site-specific recombination of DNA between loxP sites, thus making possible conditional mutagenesis, where specific genes …